January 2018-2: Second generation biocatalytic hydrogen-borrowing amination published in ChemCatChem

Amines, and in particular α-chiral amines, are important intermediates for the production of active pharmaceutical ingredients, fine chemicals and agrochemicals. Structurally simpler amines are also of interest for the manufacture of polymers, dyestuffs, pigments and other materials. Alcohols are accessible precursors for the synthesis of (chiral) amines. However, the asymmetric amination of alcohols is a […]

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January 2018-1: Towards new green chemistry using enzymes and light

Combining photocatalysis and biocatalysis for selective functionalization of carbon-hydrogen bonds Chemists at the Biocatalysis group of the University of Amsterdam’s Van ‘t Hoff Institute for Molecular Sciences (HIMS) have contributed to research that potentially renders the synthesis of certain pharmaceuticals, cosmetics and agrochemicals much simpler, cheaper and more sustainable. The results of this international project, […]

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October 2017: Two new publications by HIMS-Biocat

The HIMS-Biocat group is currently engaged, among the others, in a project funded by the European Research Council (ERC), whose aim is the design and development of efficient biocatalytic cascades and biosynthetic pathways for the sustainable production of amines. Following our break-through publication in Science on the dual-enzyme hydrogen-borrowing amination of alcohols and the further […]

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October 2016: A high-capacity glove box system from Belle Technology installed at HIMS-Biocat

The HIMS-Biocat group possesses state of the art equipment for research across chemical and biological sciences. We have recently added to our lab a new high capacity glove box. This equipment will allow us to study the properties of new enzymes that operate under anaerobic conditions. The glove box was produced by the engineers of […]

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June 2016: HRSMC Fellowship to the HIMS-Biocat group

Dr. Alejandro Orden has obtained a fellowship from the Holland Research School of Molecular Chemistry (HRSMC) to carry out six months research in our group. The project is in collaboration with the Organic Chemistry group at our institute (Dr. M. Ángeles (Tati) Fernández-Ibáñez). The project aims at developing new artificial metalloenzymes capable of promoting the […]

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May 2016: Open position for Research Technician

The Biocatalysis group is recruiting a Research Technician for supporting an exciting research programme that is funded by the European Research Council (ERC) – BioSusAmin and two other NWO grants (Sector Plan on Physics and Chemistry and NWO-echo). For more information and submission of the application, please refer to the portal of the University of […]

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January 2016-2: ‘Better than Nature’ compounds presented in the Journal of the American Chemical Society

Our group has contributed at a study on a range of synthetic biomimetic compounds that can replace the relatively expensive natural NADH and NADPH coenzymes in enzymatic conversions of industrial relevance. In the Journal of the American Chemical Society Tanja Knaus, Caroline Paul et al. show the great potential of their biomimetics in extensive studies […]

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January 2016-1: Publication in Angewandte Chemie Int. Ed.

The implementation of a one-pot multi-enzyme cascade in a single bacterial whole cell system has been recently published in Angewandte Chemie Int. Ed. (DOI: 10.1002/anie.201510028). In this research, a P450 monooxygenase, an alcohol dehydrogense and an omega-transaminase have been cloned in the same host organism to carry out the formal regio- and stereoselective amination of […]

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December 2015: Highlight on our research in Nature Chemistry and Synfacts

Dr. Jian-bo Wang and Professor Manfred T. Reetz from the “Max-Planck-Institut für Kohlenforschung” in Mülheim (Germany) have highlighted our “biocatalytic hydrogen-borrowing amination of alcohols” in the section News and Views of the December issue of Nature Chemistry (Nature Chem. DOI:10.1038/nchem.2408). Additionally, the Editorial Board of Synfacts has selected our publication for its important insights and […]

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October 2015: Spotlight on our research from the Dutch press

Description: Our novel dual-enzyme hydrogen-borrowing methodology for the amination of alcohols (Science, DOI: 10.1126/science.aac9283) has attracted the interested of the Dutch public opinion. In particular Kennislink.nl and Duurzaan have nicely summarised our research achievements in a way that is easily understandable for non scientists.  

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