Redox self-sufficient biocatalyst network for the amination of primary alcohols

Sattler, J.H.; Fuchs, M.; Tauber, K., Mutti, F.G., Faber, K.; Pfeffer, J.; Haas, T.; Kroutil, W.;

Angew. Chem. Int. Ed., 2012, 51, 9156 – 9159. DOI: 10.1002/anie.201204683


Driving the machinery: A biocatalytic redox-neutral cascade for the preparation of terminal primary amines from primary alcohols at the expense of ammonia has been established in a one-pot one-step method (see picture). Applying this artificial biocatalyst network, long-chain 1,ω-alkanediols were converted into diamines, which are building blocks for polymers, in up to 99% conversion.