PUBLICATIONS


In vitro biocatalytic pathway design: orthogonal network for the quantitative and stereospecific amination of alcohols

Knaus, T.; Cariati, L.; Masman, M. F.; Mutti, F. G. Org. Biomol. Chem., 2017, 15, 8313-8325

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Biocatalytic hydrogen-borrowing cascades

Knaus T.; Mutti F.G.; Chim. Oggi., 2017, 35(5), 34-34

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Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds

Knaus, T.; Böhmer, W.; Mutti, F.G. Green Chem., 2017, 19, 453-463

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Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes

Knaus, T.; Paul, C.E.; Levy, C.W.; de Vries, S.; Mutti, F.G.; Hollmann, F.; Scrutton, N.S. J. Am. Chem. Soc., 2016, 138 (3), 1033–1039.

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Whole-Cell Biocatalysts for Stereoselective C−H Amination Reactions

Both, P.; Busch, H.; Kelly, P.P.; Mutti, F.G.; Turner, N.J.;Flitsch, S.L. Angew. Chem. Int. Ed., 2016, 55, 1511-1513.

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Conversion of alcohols to enantiopure amines through dual enzyme hydrogen-borrowing cascades

Mutti, F.G.; Knaus, T.; Scrutton, N.S.; Breuer, M.; Turner, N. J.; Science, 2015, 349 (6255), 1525-1529.

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Asymmetric biocatalytic amination of ketones at the expense of ammonia and molecular hydrogen

Holzer, A.K.; Hiebler, K.; Mutti, F.G.; Simon, R.C.; Lauterbach, L.; Lenz, O.; Kroutil, W.; Org. Lett., 2015, 17, 2431-2433.

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Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: Application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes

Knaus, T.; Mutti, F.G.; Humphreys, L.; Turner, N.J.; Scrutton, N.S.; Org. Biomol. Chem., 2015, 13, 223-233.

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Introducing an in situ capping strategy in systems biocatalysis to access 6-aminohexanoic acid

Sattler, J.H.; Fuchs, M.; Mutti, F.G., Grischek, B.; Engel, P., Pfeffer, J.; Woodley, J. M.; Kroutil, W.; Angew. Chem. Int. Ed., 2014, 53, 14153-14157.

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Controlling stereoselectivity by enzymatic and chemical means to access enantiomerically pure (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinoline derivatives

Orden, A.A.; Schrittwieser, J.H.; Resch, V.; Mutti, F.G.; Kroutil, W.; Tetrahedron: Asymmetry, 2013, 24, 744-749.

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Asymmetric Preparation of prim-, sec-, and tert-amines employing selected biocatalysts

Kroutil, W.; Fischereder, E.-M.; Fuchs, C.S.; Lerchner, H.; Mutti, F.G.; Pressnitz, D.; Rajagopalan, A.; Sattler, J.H.; Simon, R.; Siirola, E.; Org. Process Res. Dev., 2013, 17, 751-759.

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Asymmetric synthesis of 3-substituted cyclohexylamine derivatives from prochiral diketones via three biocatalytic steps

Siirola, E.; Mutti, F.G.; Grischek, B.; Hoefler, S.F.; Fabian, W.M.F.; Grogan, G.; Kroutil, W.; Adv. Synth. Catal., 2013, 355, 1703-1708.

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Asymmetric amination of tetralone and chromanone derivatives employing ω‑transaminases

Pressnitz, D.; Fuchs, C.; Sattler, J.H.; Knaus, T.; Macheroux, P.; Mutti, F.G., Kroutil, W. ACS Catalysis, 2013, 3, 555-559.

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Alkene cleavage by white-rot Trametes hirsuta: Inducing enzyme activity by a fungicide

Rajagopalan, A.; Schober, M., Mutti, F.G., Kroutil, W.; J. Mol. Catal. B: Enzym., 2013, 90, 118-122.

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Biocatalytic synthesis of enantiopure building blocks for pharmaceuticals

Simon, R.C.; Mutti, F.G.; Kroutil, W.; Drug Discov. Today: Technol., 2013, 10, e37-44.

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Asymmetric bio-amination of ketones in organic solvents

Mutti, F.G. Kroutil W.; Adv. Synth. Catal., 2012, 354, 3409-3413.

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Redox self-sufficient biocatalyst network for the amination of primary alcohols

Sattler, J.H.; Fuchs, M.; Tauber, K., Mutti, F.G., Faber, K.; Pfeffer, J.; Haas, T.; Kroutil, W.; Angew. Chem. Int. Ed., 2012, 51, 9156 – 9159.

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Alkene cleavage catalysed by heme and nonheme enzymes: Reaction mechanisms and biocatalytic applications

Mutti, F.G. Bioinorganic chemistry and applications, 2012, Art. ID 626909, 13 pages.

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Amination of ketones by employing two new (S)-Selective ω-transaminases and the His-tagged ω-TA from Vibrio fluvialis

Mutti, F.G.; Fuchs, C.S.; Pressnitz, D.; Turrini, N.G.; Sattler, J.H.; Lerchner, A.; Skerra, A.; Kroutil, W.; Eur. J. Org. Chem., 2012, 1003 - 1007.

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Stereoselectivity of four (R)-selective transaminases for the asymmetric amination of ketones

Mutti, F.G.; Fuchs C.S.; Pressnitz, D.; Sattler, J.H.; Kroutil, W.; Adv. Synth. Catal., 2011, 353, 3227 - 3233.

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Chemoselective aerobic oxidation of 4-allylanisol by Fe(III) porphyrins in an aqueous system

Vakuliuk, O.; Mutti, F.G.; Lara, M.; Gryko, D.T.; Kroutil, W.; Tetrahedron Lett., 2011, 52, 3555 - 3557.

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A new chiral, poly-imidazole N8-ligand and the related di- and tri-copper(II) complexes: synthesis, theoretical modelling, spectroscopic properties, and biomimetic stereoselective oxidations

Mutti, F.G.; Gullotti, M.; Casella, L.; Santagostini, L.; Pagliarin, R.; Andersson, K.K.; Iozzi, M.F.; Zoppellaro, G.; Dalton Trans., 2011, 40, 5436 - 5457.

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Recent biocatalytic oxidation–reduction cascades

Schrittwieser, J.H.; Sattler, J.; Resch, V.; Mutti, F.G.; Kroutil, W.; Curr. Opin. Chem. Biol., 2011, 15, 249 – 256.

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Creating a biocatalyst for the production of an optically pure sterically hindered amine

Mutti, F.G.; Sattler, J.; Tauber, K.; Kroutil, W.; ChemCatChem, 2011, 3, 109 - 111.

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Ostensible enzyme promiscuity: Alkene cleavage by peroxidases

Mutti, F.G.; Lara, M.; Kroutil, M.; Kroutil, W.; Chem. Eur. J., 2010, 16, 14142 - 14148.

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Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

Mutti, F.G.; Orthaber, A.; Schrittwieser, J.H.; de Vries, J.G.; Pietschnig, R.; Kroutil, W.; Chem. Commun., 2010, 46, 8046 - 8048.

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Oxidative enzymatic alkene cleavage: Indications for a nonclassical enzyme mechanism

Lara, M.; Mutti, F.G.; Glueck, S.M.; Kroutil, W.; J. Am. Chem. Soc., 2009, 131, 5368 - 5369.

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Biomimetic modelling of copper enzymes: Synthesis, characterization, EPR analysis and enantioselective catalytic oxidations by a new chiral trinuclear copper(II) complex

Mutti, F.G.; Zoppellaro, G.; Gullotti, M.; Santagostini, L.; Pagliarin, R.; Andersson, K.K.; Casella, L.; Eur. J. Inorg. Chem., 2009, 554 - 566.

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Biomimetic modeling of copper complexes: A study of enantioselective catalytic oxidation on D-(+)-catechin and L-(−)-epicatechin with copper complexes

Mutti, F.G.; Pievo, R.; Sgobba, M.; Gullotti, M.; Santagostini, L.; Bioinorganic chemistry and applications, 2008, Article ID 762029, 9 pages.

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Biocatalytic cleavage of alkenes with O2 and Trametes hirsuta G FCC 047

Lara, M.; Mutti, F.G.; Glueck, S.M.; Kroutil, W.; Eur. J. Org. Chem., 2008, 3668 – 3672.

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