PUBLICATIONS


A biocatalytic method for the chemoselective aerobic oxidation of aldehydes to carboxylic acids

Knaus T., Tseliou V., Humphreys L.D., Scrutton N.S., Mutti, F.G.* Green Chemistry 20, 3931-3943 (2018),  DOI: 10.1039/C8GC01381K Herein, we present a study on the oxidation of aldehydes to carboxylic acids using three recombinant aldehyde dehydrogenases (ALDHs). The ALDHs were used in purified form with a nicotinamide oxidase (NOx), which recycles the catalytic NAD+ at the […]

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A Chimeric Styrene Monooxygenase with Increased Efficiency in Asymmetric Biocatalytic Epoxidation

Corrado M.L., Knaus T., Mutti F.G.* ChemBioChem 19, 679-686 (2018),  DOI: 10.1002/cbic.201700653 The styrene monooxygenase (SMO) system from Pseudomonas sp. consists of two enzymes (StyA and StyB). StyB catalyses the reduction of FAD at the expense of NADH. After the transfer of FADH2 from StyB to StyA, reaction with O2 generates FAD-OOH, which is the […]

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Hydrogen-Borrowing Alcohol Bioamination with Coimmobilized Dehydrogenases

Böhmer W., Knaus T., Mutti F.G.* ChemCatChem 10, 731-735 (2018),  DOI: 10.1002/cctc.201701366 The amination of alcohols is an important transformation in chemistry. The redox‐neutral (i.e., hydrogen‐borrowing) asymmetric amination of alcohols is enabled by the combination of an alcohol dehydrogenase (ADH) with an amine dehydrogenase (AmDH). In this work, we enhanced the efficiency of hydrogen‐borrowing biocatalytic […]

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Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalizations

Zhang W., Fernández-Fueyo E., Ni Y., van Schie M., Gacs J., Renirie R., Wever R., Mutti, F.G., Rother D., Alcalde M. & Hollmann F.* Nature Catalysis 1, 55-62 (2018),  DOI: 10.1038/s41929-017-0001-5 Peroxygenases offer an attractive means to address challenges in selective oxyfunctionalization chemistry. Despite this, their application in synthetic chemistry remains challenging due to their […]

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In vitro biocatalytic pathway design: orthogonal network for the quantitative and stereospecific amination of alcohols

Knaus, T.; Cariati, L.; Masman, M. F.; Mutti, F. G. Org. Biomol. Chem., 2017, 15, 8313-8325

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Biocatalytic hydrogen-borrowing cascades

Knaus T.; Mutti F.G.; Chim. Oggi., 2017, 35(5), 34-34

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Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds

Knaus, T.; Böhmer, W.; Mutti, F.G. Green Chem., 2017, 19, 453-463

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Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes

Knaus, T.; Paul, C.E.; Levy, C.W.; de Vries, S.; Mutti, F.G.; Hollmann, F.; Scrutton, N.S. J. Am. Chem. Soc., 2016, 138 (3), 1033–1039.

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Whole-Cell Biocatalysts for Stereoselective C−H Amination Reactions

Both, P.; Busch, H.; Kelly, P.P.; Mutti, F.G.; Turner, N.J.;Flitsch, S.L. Angew. Chem. Int. Ed., 2016, 55, 1511-1513.

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Conversion of alcohols to enantiopure amines through dual enzyme hydrogen-borrowing cascades

Mutti, F.G.; Knaus, T.; Scrutton, N.S.; Breuer, M.; Turner, N. J.; Science, 2015, 349 (6255), 1525-1529.

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Asymmetric biocatalytic amination of ketones at the expense of ammonia and molecular hydrogen

Holzer, A.K.; Hiebler, K.; Mutti, F.G.; Simon, R.C.; Lauterbach, L.; Lenz, O.; Kroutil, W.; Org. Lett., 2015, 17, 2431-2433.

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Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: Application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes

Knaus, T.; Mutti, F.G.; Humphreys, L.; Turner, N.J.; Scrutton, N.S.; Org. Biomol. Chem., 2015, 13, 223-233.

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Introducing an in situ capping strategy in systems biocatalysis to access 6-aminohexanoic acid

Sattler, J.H.; Fuchs, M.; Mutti, F.G., Grischek, B.; Engel, P., Pfeffer, J.; Woodley, J. M.; Kroutil, W.; Angew. Chem. Int. Ed., 2014, 53, 14153-14157.

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Controlling stereoselectivity by enzymatic and chemical means to access enantiomerically pure (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinoline derivatives

Orden, A.A.; Schrittwieser, J.H.; Resch, V.; Mutti, F.G.; Kroutil, W.; Tetrahedron: Asymmetry, 2013, 24, 744-749.

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Asymmetric Preparation of prim-, sec-, and tert-amines employing selected biocatalysts

Kroutil, W.; Fischereder, E.-M.; Fuchs, C.S.; Lerchner, H.; Mutti, F.G.; Pressnitz, D.; Rajagopalan, A.; Sattler, J.H.; Simon, R.; Siirola, E.; Org. Process Res. Dev., 2013, 17, 751-759.

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Asymmetric synthesis of 3-substituted cyclohexylamine derivatives from prochiral diketones via three biocatalytic steps

Siirola, E.; Mutti, F.G.; Grischek, B.; Hoefler, S.F.; Fabian, W.M.F.; Grogan, G.; Kroutil, W.; Adv. Synth. Catal., 2013, 355, 1703-1708.

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Asymmetric amination of tetralone and chromanone derivatives employing ω‑transaminases

Pressnitz, D.; Fuchs, C.; Sattler, J.H.; Knaus, T.; Macheroux, P.; Mutti, F.G., Kroutil, W. ACS Catalysis, 2013, 3, 555-559.

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Alkene cleavage by white-rot Trametes hirsuta: Inducing enzyme activity by a fungicide

Rajagopalan, A.; Schober, M., Mutti, F.G., Kroutil, W.; J. Mol. Catal. B: Enzym., 2013, 90, 118-122.

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Biocatalytic synthesis of enantiopure building blocks for pharmaceuticals

Simon, R.C.; Mutti, F.G.; Kroutil, W.; Drug Discov. Today: Technol., 2013, 10, e37-44.

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Asymmetric bio-amination of ketones in organic solvents

Mutti, F.G. Kroutil W.; Adv. Synth. Catal., 2012, 354, 3409-3413.

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Redox self-sufficient biocatalyst network for the amination of primary alcohols

Sattler, J.H.; Fuchs, M.; Tauber, K., Mutti, F.G., Faber, K.; Pfeffer, J.; Haas, T.; Kroutil, W.; Angew. Chem. Int. Ed., 2012, 51, 9156 – 9159.

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Alkene cleavage catalysed by heme and nonheme enzymes: Reaction mechanisms and biocatalytic applications

Mutti, F.G. Bioinorganic chemistry and applications, 2012, Art. ID 626909, 13 pages.

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Amination of ketones by employing two new (S)-Selective ω-transaminases and the His-tagged ω-TA from Vibrio fluvialis

Mutti, F.G.; Fuchs, C.S.; Pressnitz, D.; Turrini, N.G.; Sattler, J.H.; Lerchner, A.; Skerra, A.; Kroutil, W.; Eur. J. Org. Chem., 2012, 1003 - 1007.

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Stereoselectivity of four (R)-selective transaminases for the asymmetric amination of ketones

Mutti, F.G.; Fuchs C.S.; Pressnitz, D.; Sattler, J.H.; Kroutil, W.; Adv. Synth. Catal., 2011, 353, 3227 - 3233.

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Chemoselective aerobic oxidation of 4-allylanisol by Fe(III) porphyrins in an aqueous system

Vakuliuk, O.; Mutti, F.G.; Lara, M.; Gryko, D.T.; Kroutil, W.; Tetrahedron Lett., 2011, 52, 3555 - 3557.

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A new chiral, poly-imidazole N8-ligand and the related di- and tri-copper(II) complexes: synthesis, theoretical modelling, spectroscopic properties, and biomimetic stereoselective oxidations

Mutti, F.G.; Gullotti, M.; Casella, L.; Santagostini, L.; Pagliarin, R.; Andersson, K.K.; Iozzi, M.F.; Zoppellaro, G.; Dalton Trans., 2011, 40, 5436 - 5457.

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Recent biocatalytic oxidation–reduction cascades

Schrittwieser, J.H.; Sattler, J.; Resch, V.; Mutti, F.G.; Kroutil, W.; Curr. Opin. Chem. Biol., 2011, 15, 249 – 256.

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Creating a biocatalyst for the production of an optically pure sterically hindered amine

Mutti, F.G.; Sattler, J.; Tauber, K.; Kroutil, W.; ChemCatChem, 2011, 3, 109 - 111.

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Ostensible enzyme promiscuity: Alkene cleavage by peroxidases

Mutti, F.G.; Lara, M.; Kroutil, M.; Kroutil, W.; Chem. Eur. J., 2010, 16, 14142 - 14148.

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Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

Mutti, F.G.; Orthaber, A.; Schrittwieser, J.H.; de Vries, J.G.; Pietschnig, R.; Kroutil, W.; Chem. Commun., 2010, 46, 8046 - 8048.

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Oxidative enzymatic alkene cleavage: Indications for a nonclassical enzyme mechanism

Lara, M.; Mutti, F.G.; Glueck, S.M.; Kroutil, W.; J. Am. Chem. Soc., 2009, 131, 5368 - 5369.

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Biomimetic modelling of copper enzymes: Synthesis, characterization, EPR analysis and enantioselective catalytic oxidations by a new chiral trinuclear copper(II) complex

Mutti, F.G.; Zoppellaro, G.; Gullotti, M.; Santagostini, L.; Pagliarin, R.; Andersson, K.K.; Casella, L.; Eur. J. Inorg. Chem., 2009, 554 - 566.

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Biomimetic modeling of copper complexes: A study of enantioselective catalytic oxidation on D-(+)-catechin and L-(−)-epicatechin with copper complexes

Mutti, F.G.; Pievo, R.; Sgobba, M.; Gullotti, M.; Santagostini, L.; Bioinorganic chemistry and applications, 2008, Article ID 762029, 9 pages.

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Biocatalytic cleavage of alkenes with O2 and Trametes hirsuta G FCC 047

Lara, M.; Mutti, F.G.; Glueck, S.M.; Kroutil, W.; Eur. J. Org. Chem., 2008, 3668 – 3672.

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