Biocatalytic synthesis of enantiopure building blocks for pharmaceuticals

Simon, R.C.; Mutti, F.G.; Kroutil, W.;

Drug Discov. Today: Technol., 2013, 10, e37-44. DOI: 10.1016/j.ddtec.2012.08.002


Biocatalytic transformations have emerged as a viable alternative to other asymmetric chemical methods due to the intrinsic high stereoselectivity of the enzymes and the mild reaction conditions. Just a decade ago, the reaction scope of applicable biotransformations for organic synthesis was limited to a handful of reaction types. Tremendous progress has been made in the meantime so that this review presents only a small selection of the broad range of possible biotransfromations for organic synthesis available today. Lyases (hydroxynitrile lyase, aldolases) and redox enzymes like alcohol dehydrogenases, Baeyer–Villiger monooxygenase, dioxygenases, ene reductases, berberine bridge enzyme and ω-transaminases are discussed besides hydrolases.