Biocatalytic hydrogen-borrowing cascades

Knaus T., Mutti F.G.*

Chim. Oggi., 2017, 35(5), 34-34 (open access upon registration)

(monographic special issue)

The exquisite chemoselectivity and the intrinsic compatibility of enzymes have been widely exploited during the past decade for the development of multi-step biocatalytic reactions in one-pot. In this context, hydrogen-borrowing cascades permit to maximise the atom-efficiency through the internal recycling of redox equivalents, which avoids the use of additional oxidants or reductants. In this mini-review, we describe the state-of-the-art in the field of biocatalytic hydrogen-borrowing cascades and provide a future perspective for a wider implementation in organic synthesis.