Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

Mutti, F.G.; Orthaber, A.; Schrittwieser, J.H.; de Vries, J.G.; Pietschnig, R.; Kroutil, W.;

Chem. Commun., 2010, 46, 8046 – 8048. DOI: 10.1039/c0cc02813d


An iridium catalysed oxidation was coupled concurrently to an asymmetric biocatalytic reduction in one-pot; thus it was shown for the first time that iridium- and alcohol dehydrogenase-catalysed redox reactions are compatible. As a model system racemic chlorohydrins were transformed to enantioenriched chlorohydrins via an oxidation–asymmetric reduction sequence.