Recent biocatalytic oxidation–reduction cascades

Schrittwieser, J.H.; Sattler, J.; Resch, V.; Mutti, F.G.; Kroutil, W.;

Curr. Opin. Chem. Biol., 2011, 15, 249 – 256. DOI: 10.1016/j.cbpa.2010.11.010

The combination of an oxidation and a reduction in a cascade allows performing transformations in a very economic and efficient fashion. The challenge is how to combine an oxidation with a reduction in one pot, either by running the two reactions simultaneously or in a stepwise fashion without isolation of intermediates. The broader availability of various redox enzymes nowadays has triggered the recent investigation of various oxidation–reduction cascades.